604 research outputs found

    MULTI-FIELD STABILIZED FINITE ELEMENT APPROXIMATIONS FOR OLDROYD-B FLUID FLOWS

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    This work concerns with numerical simulations of creeping and inertial flows of viscoelastic fluids. The mechanical model consists of mass and momentum balance equations, coupled with the Oldroyd-B fluid. The model is approximated by a multi-field Galerkin least-squares (GLS) methodology in terms of extra-stress, velocity and pressure. The GLS method, introduced by Hughes et al. (1986) in the context of the Stokes problem for Newtonian fluidflows, allows the use of combinations of equal-order finite element interpolations and remains stable even for elastic- and inertiadominated fluid flows. Some steady simulations of Oldroyd-B fluids, flowing over a slot, are herein carried out. The influence of inertia and fluid viscoelasticity is taken into account ranging the Reynolds and Weissenberg numbers for relevant values of this flow. The results are in accordance to the viscoelastic literature and reassure the fine stability features of the GLS formulation

    A Number-Theoretic Error-Correcting Code

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    In this paper we describe a new error-correcting code (ECC) inspired by the Naccache-Stern cryptosystem. While by far less efficient than Turbo codes, the proposed ECC happens to be more efficient than some established ECCs for certain sets of parameters. The new ECC adds an appendix to the message. The appendix is the modular product of small primes representing the message bits. The receiver recomputes the product and detects transmission errors using modular division and lattice reduction

    Electromagnetic Brain Stimulation in Patients With Disorders of Consciousness

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    Severe brain injury is a common cause of coma. In some cases, despite vigilance improvement, disorders of consciousness (DoC) persist. Several states of impaired consciousness have been defined, according to whether the patient exhibits only reflexive behaviors as in the vegetative state/unresponsive wakefulness syndrome (VS/UWS) or purposeful behaviors distinct from reflexes as in the minimally conscious state (MCS). Recently, this clinical distinction has been enriched by electrophysiological and neuroimaging data resulting from a better understanding of the physiopathology of DoC. However, therapeutic options, especially pharmacological ones, remain very limited. In this context, electroceuticals, a new category of therapeutic agents which act by targeting the neural circuits with electromagnetic stimulations, started to develop in the field of DoC. We performed a systematic review of the studies evaluating therapeutics relying on the direct or indirect electro-magnetic stimulation of the brain in DoC patients. Current evidence seems to support the efficacy of deep brain stimulation (DBS) and non-invasive brain stimulation (NIBS) on consciousness in some of these patients. However, while the latter is non-invasive and well tolerated, the former is associated with potential major side effects. We propose that all chronic DoC patients should be given the possibility to benefit from NIBS, and that transcranial direct current stimulation (tDCS) should be preferred over repetitive transcranial magnetic stimulation (rTMS), based on the literature and its simple use. Surgical techniques less invasive than DBS, such as vagus nerve stimulation (VNS) might represent a good compromise between efficacy and invasiveness but still need to be further investigated

    Helminth resistance is mediated by differential activation of recruited monocyte-derived alveolar macrophages and arginine depletion

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    Macrophages are known to mediate anti-helminth responses, but it remains uncertain which subsets are involved or how macrophages actually kill helminths. Here, we show rapid monocyte recruitment to the lung after infection with the nematode parasite Nippostrongylus brasiliensis. In this inflamed tissue microenvironment, these monocytes differentiate into an alveolar macrophage (AM)-like phenotype, expressing both SiglecF and CD11c, surround invading parasitic larvae, and preferentially kill parasites in vitro. Monocyte-derived AMs (Mo-AMs) express type 2-associated markers and show a distinct remodeling of the chromatin landscape relative to tissue-derived AMs (TD-AMs). In particular, they express high amounts of arginase-1 (Arg1), which we demonstrate mediates helminth killing through L-arginine depletion. These studies indicate that recruited monocytes are selectively programmed in the pulmonary environment to express AM markers and an anti-helminth phenotype

    Electrophysiological activation by masked primes: Independence of prime-related and target-related activities

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    Visual stimuli that are made invisible by metacontrast masking (primes) have a marked influence on behavioral and psychophysiological measures such as reaction time (RT) and the lateralized readiness potential (LRP). 4 experiments are reported that shed light on the effects that masked primes have on the LRP. Participants had a go-nogo task in which the prime was associated with 1 of 2 responses even if the target required participants to refrain from responding. To analyze the electrophysiological responses, we computed the LRP and applied an averaging method separating the activation due to the prime and the target. The results demonstrated that (a) masked primes activate responses even in a nogo situation, (b) this prime-related activation is independent of masking, (c) and is also independent of whether prime and target require the same responses (congruent condition) or different responses (incongruent condition)
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